Obstructive Lung Diseases, Postoperative Pain, Pain, Cough, Fever
Acetaminophen and hydrocodone are used to relieve moderate to severe pain. This combination is often prescribed after surgeries, injuries, or dental procedures. It is also used for conditions like arthritis or chronic pain when other pain relievers are not effective. Acetaminophen helps reduce fever and mild pain, while hydrocodone addresses more intense pain by acting on the central nervous system, which includes the brain and spinal cord.
Acetaminophen works by reducing the production of prostaglandins, which are chemicals that cause pain and inflammation. It primarily acts in the brain to lower fever and relieve pain. Hydrocodone works by binding to opioid receptors in the brain and spinal cord, blocking pain signals. Together, they provide enhanced pain relief, with acetaminophen boosting the effects of hydrocodone, making the combination effective for managing pain.
The usual adult dose for acetaminophen and hydrocodone varies based on the specific formulation and the patient's needs. Typically, the combination is taken every 4 to 6 hours as needed for pain. Acetaminophen doses should not exceed 4,000 mg per day to avoid liver damage. Hydrocodone doses are usually limited to 10 mg per dose, with a maximum of 40 mg per day to prevent addiction and respiratory issues.
Common side effects of acetaminophen and hydrocodone include dizziness, drowsiness, nausea, and constipation. Acetaminophen is generally well-tolerated but can cause liver damage if taken in high doses. Hydrocodone may lead to more serious side effects like respiratory depression, which is a condition where breathing becomes inadequate, and dependency or addiction due to its opioid nature. Monitoring for these side effects is important.
Warnings for acetaminophen include the risk of liver damage, especially if taken in high doses or with alcohol. Hydrocodone carries a risk of addiction, misuse, and respiratory depression. Contraindications include severe respiratory issues, liver disease, and known hypersensitivity to either drug. Patients should avoid alcohol and other central nervous system depressants while taking this combination. Regular monitoring by a healthcare provider is recommended to ensure safe use.
US(FDA), UK(BNF)
YES
NO
Opioid Agonist
NO