Falciparum Malaria
Artemether and lumefantrine are used to treat malaria, which is a disease caused by parasites transmitted through mosquito bites. This combination is specifically for uncomplicated malaria, meaning the infection is not severe and does not involve complications like organ failure. Artemether acts quickly to reduce symptoms, while lumefantrine ensures complete clearance of parasites and prevents the infection from returning. They are not used for severe malaria or for prevention of malaria.
Artemether and lumefantrine work together to treat malaria by targeting the parasites in the blood. Artemether, which is a fast-acting component, quickly reduces the number of parasites, providing rapid relief from symptoms. Lumefantrine, which acts more slowly, ensures the complete clearance of parasites and prevents the infection from returning. Both medicines disrupt the parasite's ability to grow and multiply, making them effective in treating and preventing malaria.
The usual adult dose of artemether and lumefantrine is based on a fixed combination tablet, typically taken twice daily. The exact dose depends on the specific formulation, but it usually involves taking a set number of tablets over a three-day period. Artemether, which acts quickly, and lumefantrine, which provides sustained protection, are combined in each tablet to ensure effective treatment. It's important to follow the prescribed dosing schedule to ensure the medicine works properly.
Common side effects of artemether and lumefantrine include headache, dizziness, and nausea, which are generally mild and temporary. Some people may experience more significant adverse effects like heart rhythm changes, which are rare but require medical attention. Both medicines can cause similar side effects, but artemether is more likely to cause dizziness, while lumefantrine may lead to changes in heart rhythm. It's important to monitor for any unusual symptoms and consult a healthcare provider if they occur.
Important warnings for artemether and lumefantrine include the risk of heart rhythm changes, especially in people with existing heart conditions or those taking other medications affecting the heart. It's contraindicated in people allergic to either component. Both medicines share these warnings, but artemether may cause more dizziness, while lumefantrine may more significantly affect heart rhythm. Patients should inform their healthcare provider of any medical conditions or medications to avoid potential risks.
US(FDA), UK(BNF)
YES
NO
Antimalarial
NO