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Benserazide and levodopa are used to treat Parkinson's disease, which is a disorder affecting movement. They also help manage symptoms of Parkinsonism, which refers to conditions with similar symptoms like tremors and stiffness. By increasing dopamine levels in the brain, they improve movement and enhance the quality of life for affected individuals.
Levodopa converts into dopamine in the brain, which is a chemical that helps control movement, reducing symptoms like tremors and stiffness. Benserazide prevents levodopa from breaking down before it reaches the brain, ensuring more of it is available to be converted into dopamine. Together, they improve movement and reduce symptoms, making daily activities easier for people with Parkinson's disease.
The usual adult daily dose of benserazide and levodopa varies based on individual needs and the severity of symptoms. Typically, the combination is taken several times a day, with doses adjusted by a healthcare provider. Levodopa is often started at a low dose and gradually increased to minimize side effects. Benserazide is combined in a fixed ratio with levodopa to enhance its effectiveness.
Common side effects of benserazide and levodopa include nausea, dizziness, and sleep disturbances. Levodopa can cause involuntary movements, known as dyskinesia, which refers to uncontrolled muscle movements. Benserazide may cause gastrointestinal issues like an upset stomach. Both medicines can lead to mood changes and confusion. Significant adverse effects include heart problems and severe mood swings.
Important warnings for benserazide and levodopa include the risk of severe mood changes, such as depression or suicidal thoughts. People with a history of heart problems should use caution, as these medicines can affect heart function. Contraindications include narrow-angle glaucoma, which is a type of eye condition, and severe liver or kidney disease. Patients should inform their healthcare provider of their medical history to avoid potential risks.
UK(BNF)
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