cilostazol

ENGLISH

Synonyms

Approved Treatment Indication:

Vascular Graft Occlusion, Intermittent Claudication, Peripheral Vascular Diseases

Summary

  • What conditions Cilostazol is used for

    Cilostazol is used to treat intermittent claudication, which is leg pain due to poor blood flow. It helps improve walking distance and reduce pain by increasing blood flow to the legs.

  • How Cilostazol works in the body

    Cilostazol works by inhibiting an enzyme called phosphodiesterase, which helps widen blood vessels and improve blood flow. This action reduces symptoms like leg pain and cramping by increasing oxygen-rich blood to the muscles.

  • The usual dosages and routes of administration of Cilostazol

    The usual starting dose of Cilostazol for adults is 100 mg taken twice daily, 30 minutes before or 2 hours after breakfast and dinner. It should be taken on an empty stomach for best absorption.

  • The most commonly observed adverse effects of Cilostazol

    Common side effects of Cilostazol include headache, diarrhea, and dizziness. These occur in a small percentage of people and are generally mild.

  • Important safety warnings and contraindications of Cilostazol

    Cilostazol should not be used in people with heart failure, which is when the heart can't pump blood effectively, due to increased risk of complications. It can also interact with blood thinners, increasing bleeding risk.

Drug Status

Government Approvals

Government Approvals

US(FDA), UK(BNF)

WHO Essential Medicine

WHO Essential Medicine

NO

Known Teratogen

Known Teratogen

NO

Pharmaceutical Class

Pharmaceutical Class

Phosphodiesterase 3 Inhibitor

Controlled Drug Substance

Controlled Drug Substance

NO

Indications and Purpose

  • What is Cilostazol?

    Cilostazol is a medication used to treat intermittent claudication, which is leg pain due to poor blood flow. It belongs to a class of drugs called phosphodiesterase inhibitors, which work by widening blood vessels and improving blood flow. This helps reduce symptoms like pain and cramping, allowing you to walk longer distances without discomfort.
  • How does Cilostazol work?

    Cilostazol works by inhibiting an enzyme called phosphodiesterase, which helps widen blood vessels and improve blood flow. This action reduces symptoms of intermittent claudication, such as leg pain and cramping, by increasing the amount of oxygen-rich blood reaching the muscles. Think of it like opening a clogged pipe to allow water to flow more freely.
  • Is Cilostazol effective?

    Cilostazol is effective for treating intermittent claudication, which is pain in the legs due to poor blood flow. It works by improving blood flow and reducing symptoms like pain and cramping. Clinical studies show that Cilostazol can increase walking distance and improve quality of life for people with this condition.

Directions for Use

  • What is the usual dose of Cilostazol?

    The usual starting dose of Cilostazol for adults is 100 mg taken twice daily. This dose is typically taken 30 minutes before or 2 hours after breakfast and dinner. Dose adjustments may be necessary for certain populations, such as the elderly or those with liver issues. Always follow your doctor's specific dosing instructions for your health needs.
  • How do I take Cilostazol?

    Take Cilostazol as prescribed by your doctor, usually twice daily, 30 minutes before or 2 hours after breakfast and dinner. This medicine should not be crushed. It's important to take it on an empty stomach for best absorption. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Avoid taking two doses at once.
  • For how long do I take Cilostazol?

    Cilostazol is usually taken long-term for managing intermittent claudication, which is leg pain due to poor blood flow. You'll typically take it every day unless your doctor suggests otherwise. How long you'll need this medication depends on your body's response and any side effects you experience. Always talk with your doctor before changing or stopping your Cilostazol treatment.
  • How long does it take for Cilostazol to start working?

    Cilostazol may start to improve symptoms of intermittent claudication within a few weeks, but it can take up to 12 weeks to achieve its full effect. Individual factors like overall health and severity of symptoms can affect how quickly you notice improvements. Take Cilostazol exactly as prescribed for the best results.
  • How should I store Cilostazol?

    Store Cilostazol at room temperature, away from moisture and light. Keep it in a tightly closed container to protect it from damage. Avoid storing it in humid places like bathrooms. Always keep Cilostazol out of reach of children to prevent accidental ingestion. Check the expiration date regularly and dispose of any unused or expired medication properly.
  • How do I dispose of Cilostazol?

    Dispose of unused Cilostazol by taking it to a drug take-back program or collection site at a pharmacy or hospital. If that's not possible, mix the medication with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it away in the trash. This helps prevent harm to people and the environment.

Warnings and Precautions

  • Who should avoid taking Cilostazol?

    Cilostazol should not be used in people with heart failure, which is when the heart can't pump blood effectively, due to increased risk of complications. It's also contraindicated in those with bleeding disorders or allergies to the medication. Always consult your doctor about your medical history before starting Cilostazol.
  • Can I take Cilostazol with other prescription drugs?

    Cilostazol can interact with several medications, increasing the risk of side effects. For example, it can interact with blood thinners like warfarin, increasing bleeding risk. It may also interact with certain antifungal and antibiotic medications. Always inform your doctor about all the medications you are taking to avoid potential interactions.
  • Can Cilostazol be taken safely while pregnant?

    Cilostazol is not recommended during pregnancy due to limited safety data. Animal studies suggest potential risks, but human data is lacking. If you're pregnant or planning to become pregnant, talk with your doctor about safer alternatives. They can help create a treatment plan that protects both you and your baby.
  • Can Cilostazol be taken safely while breastfeeding?

    Cilostazol is not recommended while breastfeeding due to limited information on its safety. It's unclear if the medication passes into breast milk or affects milk production. If you're breastfeeding, consult your doctor for advice on safer medication options that allow you to nurse your baby safely.
  • Is Cilostazol safe for the elderly?

    Elderly individuals may be more vulnerable to the side effects of Cilostazol, such as dizziness and bleeding. It's important for older adults to be closely monitored by their doctor while taking this medication. Dose adjustments may be necessary to ensure safety and effectiveness. Always follow your doctor's advice.
  • Is it safe to exercise while taking Cilostazol?

    You can exercise while taking Cilostazol, but be cautious. This medication can cause dizziness, which might affect your balance during physical activity. Start with light exercises and gradually increase intensity. Stay hydrated and listen to your body. If you feel dizzy or unwell, stop exercising and rest. Consult your doctor for personalized advice.
  • Is it safe to drink alcohol while taking Cilostazol?

    It's best to avoid alcohol while taking Cilostazol. Alcohol can increase the risk of side effects like dizziness and bleeding. If you choose to drink, do so in moderation and watch for symptoms like dizziness or unusual bleeding. Talk with your doctor about alcohol use while taking Cilostazol for personalized advice.
  • What are the most common side effects of Cilostazol?

    Side effects are unwanted reactions to a medication. Common side effects of Cilostazol include headache, diarrhea, and dizziness. These occur in a small percentage of people. If you experience new symptoms after starting Cilostazol, they might be temporary or unrelated to the medication. Always talk with your doctor before stopping any medication.
  • Does Cilostazol have adverse effects?

    Adverse effects are unwanted reactions to a medication. Cilostazol can cause side effects like headache, diarrhea, and dizziness. These are generally mild and occur in a small percentage of users. Serious adverse effects include heart problems and bleeding. If you notice any new or worsening symptoms, contact your doctor immediately for advice.
  • Is Cilostazol addictive?

    Cilostazol is not addictive or habit-forming. It doesn't cause dependency or withdrawal symptoms when you stop taking it. Cilostazol works by affecting blood flow and doesn't impact brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed.
  • Does Cilostazol have any safety warnings?

    Cilostazol has important safety warnings. It can increase the risk of bleeding, especially in people with bleeding disorders or those taking blood thinners. It may also cause heart problems in some patients. If you experience chest pain, shortness of breath, or unusual bleeding, seek medical help immediately. Always follow your doctor's advice and report any concerning symptoms.
  • Is it safe to stop Cilostazol?

    Cilostazol is usually taken long-term for conditions like intermittent claudication, which is pain caused by reduced blood flow to the legs. Stopping it suddenly may worsen your symptoms. Always talk with your doctor before stopping Cilostazol. They can guide you on how to safely discontinue or adjust your medication.

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