clomifene

ENGLISH

Synonyms

Approved Treatment Indication:

Female Infertility, Male Infertility

Summary

  • What conditions clomifene is used for

    Clomifene is used to treat infertility in women who do not ovulate, which is the release of an egg from the ovary. It is often prescribed for women with polycystic ovary syndrome, which affects hormone levels and ovulation.

  • How clomifene works in the body

    Clomifene works by stimulating the release of hormones necessary for ovulation, which is the release of an egg from the ovary. It blocks estrogen receptors in the brain, causing the body to release more hormones that stimulate the ovaries.

  • The usual dosages and routes of administration of clomifene

    Clomifene is usually taken orally, once daily for five days, starting on the fifth day of the menstrual cycle. The typical starting dose is 50 mg, which may be increased to 100 mg if ovulation does not occur.

  • The most commonly observed adverse effects of clomifene

    Common side effects of clomifene include hot flashes, which are sudden feelings of warmth, and mood swings, which are changes in emotional state. Some people may also experience headaches or nausea.

  • Important safety warnings and contraindications of clomifene

    Clomifene can increase the risk of ovarian hyperstimulation syndrome, which causes the ovaries to swell and become painful. It should not be used by those with liver disease or abnormal vaginal bleeding, which is bleeding not related to the menstrual cycle.

Drug Status

Government Approvals

Government Approvals

US(FDA), UK(BNF)

WHO Essential Medicine

WHO Essential Medicine

YES

Known Teratogen

Known Teratogen

NO

Pharmaceutical Class

Pharmaceutical Class

Estrogen Agonist/Antagonist

Controlled Drug Substance

Controlled Drug Substance

NO

Indications and Purpose

  • What is clomifene?

    Clomifene is a medication used to treat infertility in women who do not ovulate, which is the release of an egg from the ovary. It belongs to a class of drugs called selective estrogen receptor modulators, which work by stimulating the release of hormones necessary for ovulation. Clomifene is primarily used to induce ovulation in women with certain types of infertility. It may also be used in other conditions as determined by your doctor.
  • How does clomifene work?

    Clomifene works by stimulating the release of hormones necessary for ovulation, which is the release of an egg from the ovary. It blocks estrogen receptors in the brain, which tricks the body into thinking estrogen levels are low. This causes the pituitary gland to release more follicle-stimulating hormone and luteinizing hormone, which stimulate the ovaries to produce and release an egg. This process helps women with certain types of infertility to ovulate and potentially conceive.
  • Is clomifene effective?

    Clomifene is effective for inducing ovulation in women with certain types of infertility. It works by stimulating the release of hormones necessary for ovulation, which is the release of an egg from the ovary. Clinical studies show that clomifene significantly increases the chances of ovulation and pregnancy in women with ovulatory disorders. However, its effectiveness can vary based on individual health conditions and other factors. Always follow your doctor's advice for the best results.

Directions for Use

  • What is the usual dose of clomifene?

    The usual starting dose of clomifene for adults is 50 mg once daily for five days, beginning on the fifth day of the menstrual cycle. If ovulation does not occur, your doctor may increase the dose to 100 mg daily in subsequent cycles. The maximum recommended dose is 100 mg per day. Always follow your doctor's specific dosing instructions, especially for special populations like the elderly.
  • How do I take clomifene?

    Take clomifene as prescribed by your doctor, usually once daily. It's often taken for five days starting on the fifth day of your menstrual cycle. You can take it with or without food, but try to take it at the same time each day. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose. Do not double up on doses. Always follow your doctor's specific instructions regarding clomifene use.
  • For how long do I take clomifene?

    Clomifene is usually taken for a short term to stimulate ovulation, which is the release of an egg from the ovary. It's typically prescribed for five days in a menstrual cycle, often starting on the fifth day. Your doctor may recommend up to six cycles of treatment if needed. The duration depends on your body's response and your doctor's advice. Always follow your doctor's instructions regarding the length of treatment with clomifene.
  • How long does it take for clomifene to start working?

    Clomifene typically starts working within the first cycle of treatment. It stimulates ovulation, which is the release of an egg from the ovary, usually occurring about 5 to 10 days after the last dose. The full therapeutic effect, which is successful ovulation and potential pregnancy, may take a few cycles. Individual factors like age and overall health can affect how quickly clomifene works. Follow your doctor's instructions for the best results.
  • How should I store clomifene?

    Store clomifene at room temperature, away from moisture and light. Keep it in a tightly closed container to protect it from damage. Avoid storing it in humid places like bathrooms, where moisture in the air could affect how well the medication works. Always store clomifene out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
  • How do I dispose of clomifene?

    Dispose of unused clomifene by taking it to a drug take-back program or collection site at a pharmacy or hospital. This ensures the medication is disposed of properly and doesn't harm people or the environment. If you can't find a take-back program, you can throw clomifene in the trash at home. First, mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and then throw it away.

Warnings and Precautions

  • Who should avoid taking clomifene?

    Clomifene should not be used if you have liver disease, which affects how your body processes substances, or if you have abnormal vaginal bleeding, which is bleeding not related to your menstrual cycle. These are absolute contraindications. Use caution if you have a history of ovarian cysts, which are fluid-filled sacs on the ovary, as clomifene can worsen this condition. Always consult your doctor to ensure clomifene is safe for you.
  • Can I take clomifene with other prescription drugs?

    Clomifene can interact with certain medications, which may increase the risk of side effects or reduce its effectiveness. For example, interactions with other fertility drugs can increase the risk of ovarian hyperstimulation syndrome, which is a condition where the ovaries swell and become painful. Always inform your doctor about all medications you are taking to avoid potential interactions. They can help manage your treatment safely.
  • Can clomifene be taken safely while pregnant?

    Clomifene is not recommended during pregnancy. It is used to induce ovulation, which is the release of an egg from the ovary, and should be stopped once pregnancy is confirmed. There is limited evidence on its safety during pregnancy, and using it could potentially harm the developing baby. If you become pregnant while taking clomifene, contact your doctor immediately for guidance on how to proceed safely.
  • Can clomifene be taken safely while breastfeeding?

    Clomifene is not recommended while breastfeeding. There is limited information on whether it passes into breast milk, but it could potentially affect milk production or the breastfed infant. If you are breastfeeding and need to take clomifene, discuss with your doctor the potential risks and benefits. They can help you decide the best course of action for both you and your baby.
  • Is clomifene safe for the elderly?

    The elderly may be more sensitive to the effects of clomifene, which can increase the risk of side effects like dizziness or mood changes. While clomifene is generally safe for older adults, careful monitoring is important. If you are elderly and taking clomifene, your doctor may adjust your dose or monitor you more closely to ensure the medication is safe and effective for you.
  • Is it safe to exercise while taking clomifene?

    You can exercise while taking clomifene, but be mindful of how your body feels. Clomifene can cause side effects like dizziness or mood swings, which might affect your exercise routine. If you feel dizzy or unusually fatigued, slow down or stop exercising and rest. Most people can maintain their regular exercise routine while taking clomifene, but check with your doctor if you have concerns about your specific situation.
  • Is it safe to drink alcohol while taking clomifene?

    It's best to avoid alcohol while taking clomifene. Alcohol can interfere with the effectiveness of the medication and may increase the risk of side effects like dizziness or nausea. If you choose to drink, do so in moderation and be aware of how your body responds. Talk with your doctor about alcohol use while taking clomifene to get personalized advice based on your specific health situation.
  • What are the most common side effects of clomifene?

    Side effects are unwanted reactions to a medication. Common side effects of clomifene include hot flashes, which are sudden feelings of warmth, and mood swings, which are changes in emotional state. These occur in a significant number of users. Some people may also experience breast tenderness or nausea. If you notice new symptoms after starting clomifene, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
  • Does clomifene have adverse effects?

    Adverse effects are unwanted reactions to a medication. Clomifene can cause hot flashes, which are sudden feelings of warmth, and mood swings, which are changes in emotional state. These effects are common. More serious effects include visual disturbances and ovarian hyperstimulation syndrome, which is a condition where the ovaries swell and become painful. If you notice any severe or unusual symptoms, contact your doctor immediately. They can help manage these effects and adjust your treatment if necessary.
  • Is clomifene addictive?

    Clomifene is not addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. Clomifene works by stimulating ovulation, which is the release of an egg from the ovary, and does not affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, clomifene does not carry this risk.
  • Does clomifene have any safety warnings?

    Clomifene has important safety warnings. It can increase the risk of ovarian hyperstimulation syndrome, which is a condition where the ovaries swell and become painful. This can lead to serious complications if not managed. Clomifene may also increase the risk of multiple pregnancies, such as twins or triplets. If you experience severe abdominal pain, nausea, or rapid weight gain, seek medical attention immediately. Always follow your doctor's advice and report any unusual symptoms.
  • Is it safe to stop clomifene?

    Clomifene is usually taken for a short term to stimulate ovulation. Stopping clomifene after completing a treatment cycle is generally safe. However, if you stop taking it before completing the prescribed course, it may affect the treatment's effectiveness. Always follow your doctor's instructions and discuss any concerns about stopping the medication. Your doctor can guide you on the best approach to manage your treatment safely.

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