HIV Infections, Acquired Immunodeficiency Syndrome
Cobicistat and darunavir are used together to treat HIV, which is the virus that causes AIDS. They help control the virus and improve the immune system's function. By reducing the amount of virus in the body, they help prevent the progression of HIV to AIDS. This combination is part of antiretroviral therapy, which is a treatment plan used to manage HIV infection effectively.
Cobicistat acts as a booster, which means it enhances the effectiveness of darunavir by slowing its breakdown in the body. Darunavir is a protease inhibitor, which means it blocks a specific enzyme the virus needs to multiply. Together, they help reduce the amount of virus in the body, improving the immune system's function. This combination starts working within a few hours, but it may take several weeks to see the full effect on the virus levels.
The usual adult daily dose for cobicistat is 150 mg, taken once a day. For darunavir, the typical dose is 800 mg, also taken once daily. Both medicines are usually taken together with food to enhance absorption and effectiveness. It's important to follow the healthcare provider's instructions regarding dosing to ensure the best possible outcome in managing HIV. Taking them as prescribed helps maintain the right levels in the body for effective treatment.
Common side effects of cobicistat and darunavir include nausea, diarrhea, and headache. Some people may experience more serious effects like liver problems, which can cause yellowing of the skin or eyes, and severe skin reactions, which can include rash and blisters. Cobicistat can also cause kidney issues, while darunavir may lead to increased blood sugar levels. It's important to monitor for these effects and report any unusual symptoms to a healthcare provider.
Cobicistat and darunavir can interact with several other medications, which can affect how well they work or increase side effects. Cobicistat can increase the levels of certain drugs in the blood, leading to potential toxicity. Darunavir can also interact with other protease inhibitors and certain cholesterol-lowering drugs. Monitoring involves regular blood tests to check drug levels and liver function, as well as reviewing all medications with a healthcare provider to avoid harmful interactions.
US(FDA), UK(BNF)
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