Menorrhagia, Dysmenorrhea, Fever, Irritable Bowel Syndrome, Premenstrual Syndrome
Dicyclomine is used to relieve muscle spasms in the stomach and intestines, often associated with irritable bowel syndrome, which is a disorder causing abdominal pain and cramping. Mefenamic acid is used to reduce pain and inflammation, particularly for menstrual cramps, which are painful contractions of the uterus. Both medicines aim to alleviate discomfort, though they target different symptoms. Together, they can provide a comprehensive approach to managing pain and muscle spasms.
Dicyclomine works by relaxing the muscles in the stomach and intestines, which helps to relieve cramps and spasms associated with irritable bowel syndrome. It does this by blocking the action of acetylcholine, which is a neurotransmitter that causes muscle contractions. Mefenamic acid works by reducing inflammation and pain through its action as a non-steroidal anti-inflammatory drug (NSAID), which inhibits the production of prostaglandins, which are chemicals in the body that cause inflammation and pain.
The usual adult dose for dicyclomine is typically 20 mg taken four times a day, but it may be adjusted based on individual needs and response. Mefenamic acid is usually prescribed at a dose of 500 mg initially, followed by 250 mg every 6 hours as needed, not exceeding 7 days of use. Both medicines are taken orally, which means they are swallowed and absorbed through the digestive system. It's important to follow the prescribed dosage to ensure effectiveness and minimize the risk of side effects.
Common side effects of dicyclomine include dry mouth, dizziness, blurred vision, and constipation, which are related to its action on the nervous system. Mefenamic acid can cause side effects like stomach upset, nausea, and diarrhea, which are typical for NSAIDs. Both medicines can cause dizziness and should be used with caution when driving or operating machinery. Significant adverse effects may include allergic reactions or severe gastrointestinal issues, such as ulcers or bleeding, particularly with mefenamic acid.
Dicyclomine should not be used by individuals with certain conditions like glaucoma, which is increased pressure in the eye, or myasthenia gravis, which is a muscle weakness disorder, due to its anticholinergic effects. Mefenamic acid is contraindicated in people with a history of gastrointestinal bleeding or ulcers, as it can exacerbate these conditions. Both medicines should be used with caution in individuals with kidney or liver issues. It's crucial to follow medical advice and disclose all health conditions to a healthcare provider to avoid serious complications and ensure safe use.
US(FDA)
NO
NO
Anticholinergic, Nonsteroidal Anti-inflammatory Drug
NO