doravirine

ENGLISH

Synonyms

Approved Treatment Indication:

NA

Summary

  • What conditions Doravirine is used for

    Doravirine is used to treat HIV-1 infection, which is a virus that attacks the immune system. It helps control the virus and improve immune function.

  • How Doravirine works in the body

    Doravirine works by blocking a protein called reverse transcriptase, which the HIV virus needs to multiply. This helps control the infection and allows the immune system to function better.

  • The usual dosages and routes of administration of Doravirine

    The usual dose of Doravirine for adults is one 100 mg tablet taken once daily, with or without food. Always follow your doctor's specific dosing instructions.

  • The most commonly observed adverse effects of Doravirine

    Common side effects of Doravirine include nausea, dizziness, and fatigue, which refer to feeling tired. These effects are usually mild and temporary.

  • Important safety warnings and contraindications of Doravirine

    Doravirine can cause liver problems, so watch for symptoms like yellowing of the skin or eyes. Don't take it if you're allergic to it or its ingredients.

Drug Status

Government Approvals

Government Approvals

US(FDA), UK(BNF)

WHO Essential Medicine

WHO Essential Medicine

NO

Known Teratogen

Known Teratogen

NO

Pharmaceutical Class

Pharmaceutical Class

Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor

Controlled Drug Substance

Controlled Drug Substance

NO

Indications and Purpose

  • What is Doravirine?

    Doravirine is a medication used to treat HIV-1 infection. It belongs to a class of drugs called non-nucleoside reverse transcriptase inhibitors, which work by blocking a protein the virus needs to multiply. This helps control the infection and improve immune function. Doravirine is usually used in combination with other HIV medications as part of a complete treatment plan.
  • How does Doravirine work?

    Doravirine works by blocking a protein called reverse transcriptase, which the HIV virus needs to multiply. Think of it like putting a lock on a door to stop unwanted guests. By blocking this protein, Doravirine helps control the infection and allows your immune system to function better. This makes it an important part of HIV treatment.
  • Is Doravirine effective?

    Doravirine is effective in treating HIV-1 infection. It works by blocking a protein the virus needs to multiply, helping to control the infection. Clinical studies show that Doravirine effectively reduces viral load and increases CD4 cell counts, which are important for a healthy immune system. Always follow your doctor's instructions to get the best results from your treatment.

Directions for Use

  • What is the usual dose of Doravirine?

    The usual dose of Doravirine for adults is one 100 mg tablet taken once daily, with or without food. Always follow your doctor's specific dosing instructions for your personal health needs. If you have any questions about your dose, talk with your healthcare provider.
  • How do I take Doravirine?

    Doravirine is usually taken as a once-daily pill. You can take it with or without food. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Never take two doses at once. Always follow your doctor's specific instructions about how to take this medication.
  • For how long do I take Doravirine?

    Doravirine is usually a long-term medication for managing HIV-1 infection. You'll typically take it every day as part of your ongoing treatment unless your doctor suggests otherwise. How long you'll need this medication depends on your body's response and any side effects you experience. Always talk with your doctor before changing or stopping your Doravirine treatment.
  • How long does it take for Doravirine to start working?

    Doravirine begins working shortly after you take it, but it may take several weeks to see significant changes in your viral load. Regular blood tests will help monitor your progress. How quickly the medication works can depend on your overall health and adherence to the treatment plan. Always take Doravirine exactly as prescribed for the best results.
  • How should I store Doravirine?

    Store Doravirine at room temperature, away from moisture and light. Keep it in its original container with the lid tightly closed. Don't store it in the bathroom, where humidity can affect the medication. Always keep Doravirine out of reach of children to prevent accidental ingestion. Check the expiration date regularly and dispose of any unused or expired medication properly.
  • How do I dispose of Doravirine?

    To dispose of Doravirine, take it to a drug take-back program or collection site at a pharmacy or hospital. If you can't find a take-back program, you can throw it in the trash at home. First, mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it away. This helps prevent harm to people and the environment.

Warnings and Precautions

  • Who should avoid taking Doravirine?

    Don't take Doravirine if you're allergic to it or its ingredients. Serious allergic reactions require immediate medical help. Doravirine should be used with caution in people with severe liver problems. Always consult your doctor about any concerns or conditions you have before starting Doravirine.
  • Can I take Doravirine with other prescription drugs?

    Doravirine can interact with certain medications, such as rifampin, which can reduce its effectiveness. It's important to tell your doctor about all the medications you're taking, including over-the-counter drugs and supplements. Your doctor can help manage any potential interactions to ensure your treatment is safe and effective.
  • Can Doravirine be taken safely while pregnant?

    The safety of Doravirine during pregnancy isn't well-established. Limited data is available, so it's important to discuss with your doctor if you're pregnant or planning to become pregnant. Your doctor can help determine the safest treatment plan for you and your baby. Always follow your healthcare provider's advice regarding medication use during pregnancy.
  • Can Doravirine be taken safely while breastfeeding?

    The safety of Doravirine while breastfeeding isn't well-established. It's unclear if Doravirine passes into breast milk. If you're breastfeeding or planning to breastfeed, talk with your doctor. They can help determine the safest treatment plan for you and your baby. Always follow your healthcare provider's advice regarding medication use while breastfeeding.
  • Is Doravirine safe for the elderly?

    Elderly individuals may be more sensitive to the effects of medications, including Doravirine. It's generally safe for older adults, but they should be monitored for side effects like dizziness or liver issues. Always follow your doctor's advice and report any new or worsening symptoms while taking Doravirine.
  • Is it safe to exercise while taking Doravirine?

    You can exercise while taking Doravirine, but listen to your body. If you feel dizzy or fatigued, take a break. Staying hydrated is important, especially during physical activity. Most people can maintain their regular exercise routine while taking Doravirine. If you have concerns about your specific situation, check with your doctor.
  • Is it safe to drink alcohol while taking Doravirine?

    It's best to avoid alcohol while taking Doravirine. Alcohol can affect your liver, and since Doravirine can also impact liver function, combining the two might increase the risk of liver problems. If you choose to drink, do so in moderation and discuss it with your doctor. They can provide personalized advice based on your health situation.
  • What are the most common side effects of Doravirine?

    Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Doravirine include nausea, dizziness, and fatigue. These effects vary from person to person and are usually mild. If you notice new symptoms after starting Doravirine, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
  • Does Doravirine have adverse effects?

    Adverse effects are unwanted reactions to a medication. With Doravirine, common adverse effects include nausea, dizziness, and fatigue. These effects are usually mild. Serious side effects, like liver problems, are rare but require immediate medical attention. Always tell your doctor about any new or worsening symptoms while taking Doravirine.
  • Is Doravirine addictive?

    Doravirine is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. If you have concerns about medication dependence, you can feel confident that Doravirine doesn't carry this risk while managing your health condition.
  • Does Doravirine have any safety warnings?

    Doravirine has important safety warnings. It can cause liver problems, so watch for symptoms like yellowing of the skin or eyes, dark urine, or stomach pain. If you experience these, contact your doctor immediately. Doravirine can also cause immune reconstitution syndrome, which is when your immune system starts to recover and causes inflammation. Always follow your doctor's advice and report any new or worsening symptoms.
  • Is it safe to stop Doravirine?

    It's important not to stop taking Doravirine without consulting your doctor. Stopping suddenly can affect your health condition, especially if you're using it for HIV treatment. Your doctor might suggest a plan to safely stop or switch medications if needed. Always follow your healthcare provider's advice to protect your health.

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