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Duloxetine is used to treat depression, which is a mood disorder causing persistent sadness, anxiety, which is excessive worry, and nerve pain, which is pain caused by damaged nerves. Pregabalin is used for nerve pain, epilepsy, which is a condition causing seizures, and fibromyalgia, which is a disorder causing widespread muscle pain and tenderness. Both medications help manage nerve pain, but Duloxetine is unique in treating mood disorders, while Pregabalin is effective for epilepsy and fibromyalgia.
Duloxetine works by increasing serotonin and norepinephrine levels, which are chemicals in the brain that help regulate mood and pain. Pregabalin calms overactive nerves, which helps reduce pain and seizures. While both medications manage nerve pain, Duloxetine affects brain chemicals, and Pregabalin directly calms nerve activity. Their unique mechanisms make them suitable for different conditions, with Duloxetine focusing on mood regulation and Pregabalin on nerve calming.
Duloxetine is usually started at 30 mg once daily, which can be increased to 60 mg per day, and is taken orally. Pregabalin typically starts at 150 mg per day, divided into two or three doses, and can be increased to 300 mg per day, also taken orally. Both medications are taken by mouth and can be taken with or without food. It's important to follow a doctor's instructions for dosage adjustments to ensure safety and effectiveness.
Duloxetine can cause nausea, dry mouth, and sleepiness, with a risk of liver damage. Pregabalin often leads to dizziness, sleepiness, weight gain, and swelling in the hands and feet. Both medications share common side effects like dizziness and sleepiness, but Duloxetine is more associated with digestive issues, while Pregabalin is linked to weight changes and swelling. It's important to consult a doctor if side effects are severe or concerning.
Duloxetine may increase the risk of suicidal thoughts, especially in young adults, and can cause liver damage, so people with liver disease should avoid it. Pregabalin can cause dizziness and drowsiness, affecting the ability to drive or operate machinery, and may lead to weight gain and swelling. Both medications can cause allergic reactions and interact with alcohol, increasing drowsiness. It's crucial to avoid stopping these medications suddenly to prevent withdrawal symptoms.
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