fenfluramine

ENGLISH

Synonyms

Approved Treatment Indication:

Obesity, Bulimia, Autistic Disorder

Summary

  • What conditions fenfluramine is used for

    Fenfluramine is used to treat seizures associated with Dravet syndrome, which is a severe form of epilepsy. It helps reduce the frequency and severity of seizures, making it an important treatment option for managing this condition.

  • How fenfluramine works in the body

    Fenfluramine works by affecting certain chemicals in the brain, which helps control seizures. It reduces the frequency and severity of seizures by calming the brain's activity, similar to turning down the volume on a radio to reduce noise.

  • The usual dosages and routes of administration of fenfluramine

    The usual starting dose of fenfluramine for adults is 0.2 mg/kg taken twice daily, which means two times a day. The maximum recommended dose is 0.35 mg/kg twice daily. It should be taken exactly as prescribed by a doctor, with or without food.

  • The most commonly observed adverse effects of fenfluramine

    Common side effects of fenfluramine include decreased appetite, which means less desire to eat, fatigue, which is feeling very tired, and diarrhea, which is frequent loose or watery stools. These effects vary from person to person.

  • Important safety warnings and contraindications of fenfluramine

    Fenfluramine can increase the risk of heart valve problems and pulmonary hypertension, which is high blood pressure in the lungs. Regular heart monitoring is recommended. It is contraindicated in patients with a history of these conditions.

Drug Status

Government Approvals

Government Approvals

US(FDA), UK(BNF)

WHO Essential Medicine

WHO Essential Medicine

NO

Known Teratogen

Known Teratogen

NO

Pharmaceutical Class

Pharmaceutical Class

NA

Controlled Drug Substance

Controlled Drug Substance

NO

Indications and Purpose

  • What is fenfluramine?

    Fenfluramine is a medication used to treat seizures associated with Dravet syndrome, a severe form of epilepsy. It works by affecting certain chemicals in the brain to help control seizures. Fenfluramine is usually used in combination with other seizure medications to improve its effectiveness. It's an important treatment option for managing this condition.
  • How does fenfluramine work?

    Fenfluramine works by affecting certain chemicals in the brain to help control seizures. It reduces the frequency and severity of seizures in patients with Dravet syndrome, a severe form of epilepsy. Think of it like adjusting the volume on a radio to reduce noise. This medication helps calm the brain's activity, making it an important treatment option for managing seizures.
  • Is fenfluramine effective?

    Fenfluramine is effective in treating seizures associated with Dravet syndrome, a severe form of epilepsy. Clinical studies show it significantly reduces the frequency of seizures in patients. This medication works by affecting certain chemicals in the brain to help control seizures. Fenfluramine is an important treatment option for managing this condition.

Directions for Use

  • What is the usual dose of fenfluramine?

    The usual starting dose of fenfluramine for adults is 0.2 mg/kg twice daily. Your doctor may adjust your dose based on your response and needs. The maximum recommended dose is 0.35 mg/kg twice daily. Always follow your doctor's specific dosing instructions for your personal health needs. Children and elderly patients may require different dosing.
  • How do I take fenfluramine?

    Take fenfluramine exactly as prescribed by your doctor. It's usually taken twice daily, with or without food. Do not crush or chew the tablets. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Never take two doses at once. Always follow your doctor's specific advice about diet and fluid intake while taking this medication.
  • For how long do I take fenfluramine?

    Fenfluramine is usually a long-term medication for managing seizures associated with Dravet syndrome. You'll typically take it every day as a lifelong treatment unless your doctor suggests otherwise. Stopping this medication without medical advice could cause your condition to worsen. Always talk with your doctor before changing or stopping your fenfluramine treatment.
  • How long does it take for fenfluramine to start working?

    Fenfluramine begins working in your body shortly after you take it. However, you may not notice all the benefits right away. For seizures, you might see some improvement within days, but more significant changes typically take several weeks. How quickly the medication works can depend on your overall health and response to treatment. Take it exactly as prescribed for the best results.
  • How should I store fenfluramine?

    Store fenfluramine at room temperature, away from moisture and light. Keep it in a tightly closed container to protect it from damage. Don't store your medicine in humid places like bathrooms. Always store fenfluramine out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
  • How do I dispose of fenfluramine?

    Dispose of unused fenfluramine through a drug take-back program or collection site at a pharmacy or hospital. If you can't find a take-back program, you can throw it in the trash at home. First, take it out of its original container, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.

Warnings and Precautions

  • Who should avoid taking fenfluramine?

    Don't take fenfluramine if you're allergic to it or its ingredients. It's contraindicated in patients with a history of heart valve problems or pulmonary hypertension, which is high blood pressure in the lungs. These conditions can worsen with fenfluramine use. Always consult your doctor about any concerns or pre-existing conditions before starting this medication.
  • Can I take fenfluramine with other prescription drugs?

    Fenfluramine can interact with other medications, increasing the risk of side effects. It's important to inform your doctor about all the medicines you take, including over-the-counter drugs and supplements. Your doctor can help manage potential interactions and adjust your treatment plan as needed. Regular monitoring can help ensure your treatment is safe and effective.
  • Can fenfluramine be taken safely while pregnant?

    Fenfluramine is not recommended during pregnancy due to limited safety data. Animal studies suggest potential risks, but human data is lacking. Uncontrolled seizures during pregnancy can harm both mother and baby. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition. Your doctor can help create a pregnancy-specific treatment plan.
  • Can fenfluramine be taken safely while breastfeeding?

    Fenfluramine is not recommended while breastfeeding due to limited safety data. It's unclear if the medication passes into human breast milk. Animal studies suggest potential risks to the developing infant. If you're taking fenfluramine and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
  • Is fenfluramine safe for the elderly?

    Elderly patients may be more vulnerable to the side effects of fenfluramine, such as dizziness or heart issues. Regular monitoring is important to ensure safety. The doctor may adjust the dose based on the patient's response and health condition. Always consult with a healthcare provider to discuss the risks and benefits of fenfluramine for elderly patients.
  • Is it safe to exercise while taking fenfluramine?

    You can exercise while taking fenfluramine, but be cautious. This medication can cause dizziness or fatigue, which might affect your exercise capacity. To exercise safely, start with light activities and gradually increase intensity. Drink plenty of water before, during, and after physical activity. If you feel dizzy or unusually tired, stop exercising and rest. Consult your doctor if you have concerns.
  • Is it safe to drink alcohol while taking fenfluramine?

    It's best to avoid alcohol while taking fenfluramine. Alcohol can increase the risk of side effects like dizziness and drowsiness. It may also interfere with the medication's effectiveness. If you choose to drink occasionally, limit your alcohol intake and watch for warning signs like dizziness or nausea. Talk with your doctor about alcohol use while taking fenfluramine.
  • What are the most common side effects of fenfluramine?

    Side effects are unwanted reactions that can happen when taking a medication. Common side effects of fenfluramine include decreased appetite, fatigue, and diarrhea. These effects vary from person to person. If you notice new symptoms after starting fenfluramine, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
  • Does fenfluramine have adverse effects?

    Adverse effects are unwanted reactions to a medication. Fenfluramine can cause side effects like decreased appetite, fatigue, and diarrhea. Serious effects include heart valve problems and pulmonary hypertension, which is high blood pressure in the lungs. If you notice any new or worsening symptoms, contact your doctor immediately. Regular monitoring can help manage these effects.
  • Is fenfluramine addictive?

    Fenfluramine is not considered addictive or habit-forming. It doesn't cause dependency or withdrawal symptoms when you stop taking it. Fenfluramine works by affecting certain chemicals in the brain to help control seizures. This mechanism doesn't lead to addiction. If you have concerns about medication dependence, discuss them with your doctor.
  • Does fenfluramine have any safety warnings?

    Yes, fenfluramine has important safety warnings. It can increase the risk of heart valve problems and pulmonary hypertension, which is high blood pressure in the lungs. Regular heart monitoring is recommended. Not adhering to these warnings can lead to serious heart issues. If you experience symptoms like shortness of breath or chest pain, seek medical help immediately.
  • Is it safe to stop fenfluramine?

    Stopping fenfluramine suddenly can cause serious problems, especially if you're taking it for seizures. Your condition might worsen, and you could experience withdrawal symptoms. Always talk with your doctor before stopping fenfluramine. They might suggest gradually reducing your dose to keep your condition under control. Your doctor will help you make any medication changes safely.

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