hydrochlorothiazide + telmisartan
Synonyms
Approved Treatment Indication:
Hypertension, Edema, Hirsutism, Ascites, Heart Failure, Hypokalemia, Nephrotic Syndrome, Hyperaldosteronism
Summary
What conditions hydrochlorothiazide and telmisartan is used for
Hydrochlorothiazide and telmisartan are used to treat high blood pressure, which is also known as hypertension. By lowering blood pressure, they help reduce the risk of complications such as heart attacks, strokes, and kidney problems. Hydrochlorothiazide can also be used to treat fluid retention, which refers to the buildup of excess fluid in the body, while telmisartan is specifically used for its blood pressure-lowering effects.
How hydrochlorothiazide and telmisartan works in the body
Hydrochlorothiazide works by helping the kidneys remove excess salt and water from the body, which reduces fluid buildup and lowers blood pressure. Telmisartan works by blocking a substance called angiotensin II, which causes blood vessels to tighten. By blocking this substance, telmisartan helps relax and widen blood vessels, further lowering blood pressure. Both medicines aim to reduce blood pressure, but they do so through different mechanisms, making them effective when used together.
The usual dosages and routes of administration of hydrochlorothiazide and telmisartan
The usual adult daily dose of hydrochlorothiazide ranges from 12.5 mg to 50 mg, depending on the individual's needs and response. Telmisartan is typically prescribed at a dose of 20 mg to 80 mg per day. The exact dose for the combination of these medicines will depend on the patient's condition and how they respond to treatment. It's important to follow the healthcare provider's instructions and not to adjust the dose without consulting them.
The most commonly observed adverse effects of hydrochlorothiazide and telmisartan
Common side effects of hydrochlorothiazide include increased urination, dizziness, and electrolyte imbalances, which refer to changes in the levels of minerals in the blood. Telmisartan may cause dizziness, fatigue, and back pain. Both medicines can lead to low blood pressure, which is a condition where blood pressure drops too low, causing dizziness or fainting. Significant adverse effects may include kidney problems and allergic reactions. It's important to monitor for these side effects and consult a healthcare provider if they occur.
Important safety warnings and contraindications of hydrochlorothiazide and telmisartan
Hydrochlorothiazide is generally not recommended during pregnancy as it can affect the developing baby. Telmisartan is also not advised during pregnancy, especially in the second and third trimesters, as it can harm the fetus. Both medicines can lead to complications such as low blood pressure in the mother and developmental issues in the baby. It's crucial for pregnant women to consult their healthcare provider before using these medications to discuss safer alternatives.
Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
NO
Pharmaceutical Class
NO
Controlled Drug Substance
NO
Indications and Purpose
How does combination of Telmisartan and Hydrochlorothiazide work?
Telmisartan works by blocking angiotensin II receptors, preventing blood vessels from constricting, which helps lower blood pressure and improve blood flow. Hydrochlorothiazide acts as a diuretic, promoting the excretion of excess salt and water through the kidneys, reducing fluid retention and blood pressure. Together, they provide a dual mechanism to effectively manage hypertension by both reducing fluid volume and relaxing blood vessels.How does combination of Hydrochlorothiazide and Telmisartan work?
The combination of Hydrochlorothiazide and Telmisartan is used to treat high blood pressure. Hydrochlorothiazide is a diuretic, often called a 'water pill,' which helps your body get rid of extra salt and water by making you urinate more. This helps to lower blood pressure. Telmisartan is an angiotensin II receptor blocker (ARB). It works by relaxing blood vessels so that blood can flow more easily, which also helps to lower blood pressure. Together, these medications help to control blood pressure more effectively than either would alone.How effective is combination of Hydrochlorothiazide and Telmisartan?
This combination is effective in lowering blood pressure more than either drug alone. By combining these two medications, they work together to provide a more comprehensive approach to managing hypertension, which can help reduce the risk of heart attacks and strokes.
The combination is generally well-tolerated, but like all medications, it may have side effects. It's important for patients to follow their healthcare provider's instructions and report any unusual symptoms.
Overall, the combination of Hydrochlorothiazide and Telmisartan is considered effective for controlling high blood pressure, especially in patients who may not achieve desired results with a single medication.How effective is combination of Telmisartan and Hydrochlorothiazide?
Clinical trials have demonstrated that Telmisartan and Hydrochlorothiazide effectively lower blood pressure, reducing the risk of cardiovascular events such as stroke and heart attack. Telmisartan's ability to block angiotensin II receptors leads to improved blood flow, while Hydrochlorothiazide's diuretic action helps reduce fluid volume. Together, they provide a synergistic effect, enhancing overall blood pressure control. The combination has been shown to be more effective than either medication alone in achieving target blood pressure levels.
Directions for Use
What is the usual dose of combination of Telmisartan and Hydrochlorothiazide?
The usual adult daily dose for Telmisartan is typically 40 to 80 mg once daily, while Hydrochlorothiazide is usually prescribed at 12.5 to 25 mg once daily. When combined, the starting dose is often 40 mg of Telmisartan with 12.5 mg of Hydrochlorothiazide, which can be adjusted based on the patient's response and needs. Both medications are taken orally and can be adjusted by healthcare providers to achieve optimal blood pressure control.What is the usual dose of combination of Hydrochlorothiazide and Telmisartan?
The usual dose of the combination of Hydrochlorothiazide and Telmisartan can vary depending on the specific needs of the patient, but a common starting dose is 40 mg of Telmisartan and 12.5 mg of Hydrochlorothiazide taken once daily. It's important to follow a healthcare provider's instructions for the correct dosage.
How does one take combination of Telmisartan and Hydrochlorothiazide?
Telmisartan and Hydrochlorothiazide can be taken with or without food, but it's important to take them at the same time each day to maintain consistent blood levels. Patients should avoid using salt substitutes containing potassium without consulting their doctor, as these can interact with the medication. If prescribed a low-salt diet, it's crucial to follow these dietary instructions carefully to enhance the medication's effectiveness and reduce the risk of side effects.How does one take combination of Hydrochlorothiazide and Telmisartan?
To take this combination, follow your doctor's instructions carefully. Typically, it is taken once a day, with or without food. It's important to take it at the same time each day to maintain an even level of medication in your body.
Do not stop taking the medication without consulting your doctor, even if you feel well, as high blood pressure often has no symptoms. If you miss a dose, take it as soon as you remember, but skip it if it's almost time for your next dose. Never take two doses at once.
Always check with your healthcare provider or pharmacist if you have any questions or concerns about your medication.For how long is combination of Telmisartan and Hydrochlorothiazide taken?
Telmisartan and Hydrochlorothiazide are typically used as long-term treatments for managing high blood pressure. While Hydrochlorothiazide provides immediate diuretic effects, Telmisartan offers sustained blood pressure control. Patients are usually advised to continue taking these medications even if they feel well, as they manage but do not cure hypertension. Regular monitoring by a healthcare provider is essential to ensure effectiveness and adjust dosages as needed.For how long is combination of Hydrochlorothiazide and Telmisartan taken?
The combination of Hydrochlorothiazide and Telmisartan is typically taken as a long-term treatment for managing high blood pressure. The duration of treatment can vary depending on individual health needs and how well the medication is controlling blood pressure. It's important to follow your healthcare provider's instructions and not to stop taking the medication without consulting them, as stopping suddenly can lead to a rise in blood pressure.How long does it take for combination of Telmisartan and Hydrochlorothiazide to work?
Telmisartan and Hydrochlorothiazide work together to manage high blood pressure. Telmisartan, an angiotensin II receptor antagonist, typically begins to lower blood pressure within 3 hours, with full effects seen in about 4 weeks. Hydrochlorothiazide, a diuretic, starts working within 2 hours, peaking at around 4 hours, and its effects last for 6 to 12 hours. Together, they provide a comprehensive approach to blood pressure management, with Telmisartan offering long-term control and Hydrochlorothiazide providing more immediate diuretic effects.How long does it take for combination of Hydrochlorothiazide and Telmisartan to work?
The combination of Hydrochlorothiazide and Telmisartan typically starts to work within a few hours after taking the first dose. However, it may take several weeks to experience the full benefits in terms of blood pressure reduction.
Warnings and Precautions
Are there harms and risks from taking combination of Telmisartan and Hydrochlorothiazide?
Common side effects of Telmisartan and Hydrochlorothiazide include dizziness, fatigue, and upper respiratory tract infections. Hydrochlorothiazide may cause frequent urination, while Telmisartan can lead to back pain and sinus congestion. Significant adverse effects include electrolyte imbalances, dehydration, and potential kidney issues. Both medications can cause allergic reactions, and Telmisartan has a specific warning for fetal toxicity if taken during pregnancy. Patients should report any severe or persistent side effects to their healthcare provider.Are there harms and risks from taking combination of Hydrochlorothiazide and Telmisartan?
Hydrochlorothiazide and Telmisartan are medications often used together to treat high blood pressure. Hydrochlorothiazide is a diuretic, which helps your body get rid of extra salt and water, while Telmisartan is an angiotensin receptor blocker that helps relax blood vessels. Taking these medications together can be effective, but there are potential risks and side effects. Common side effects include dizziness, lightheadedness, or dehydration, especially when you first start taking them or if your dose is increased. This happens because the medications can lower your blood pressure too much or cause your body to lose too much water. More serious risks include kidney problems, as these drugs can affect how well your kidneys work. They can also cause an imbalance in electrolytes, which are minerals in your blood that are important for your body's functions. Symptoms of an electrolyte imbalance might include muscle cramps, weakness, or an irregular heartbeat. It's important to have regular check-ups with your healthcare provider to monitor your blood pressure, kidney function, and electrolyte levels while taking these medications. Always discuss any concerns or side effects with your doctor, who can adjust your treatment if necessary.Can I take combination of Telmisartan and Hydrochlorothiazide with other prescription drugs?
Telmisartan and Hydrochlorothiazide can interact with several prescription drugs. Nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce their effectiveness and increase the risk of kidney problems. Combining with other blood pressure medications can enhance hypotensive effects. Telmisartan should not be used with aliskiren in patients with diabetes due to increased risk of adverse effects. Additionally, Hydrochlorothiazide can interact with lithium, increasing the risk of lithium toxicity. Patients should inform their healthcare provider of all medications they are taking to manage potential interactions.Can I take combination of Hydrochlorothiazide and Telmisartan with other prescription drugs?
Hydrochlorothiazide and Telmisartan are medications often used together to manage high blood pressure. Hydrochlorothiazide is a diuretic, which helps your body get rid of excess salt and water, while Telmisartan is an angiotensin receptor blocker that helps relax blood vessels.
When taking these medications, it's important to be cautious about combining them with other prescription drugs. Some medications can interact with Hydrochlorothiazide and Telmisartan, potentially leading to increased side effects or reduced effectiveness. For example, combining them with other blood pressure medications can sometimes lower your blood pressure too much.
Additionally, certain non-prescription drugs, like non-steroidal anti-inflammatory drugs (NSAIDs), can affect how well these medications work. It's crucial to inform your healthcare provider about all the medications you are taking, including over-the-counter drugs and supplements, to ensure safe and effective treatment.Can I take combination of Hydrochlorothiazide and Telmisartan if I am pregnant?
It is generally not recommended to take a combination of Hydrochlorothiazide and Telmisartan during pregnancy. Medications like Telmisartan, which belong to a group called angiotensin II receptor blockers (ARBs), can harm the developing baby, especially in the second and third trimesters. Hydrochlorothiazide, a diuretic, is also typically avoided during pregnancy unless absolutely necessary, as it can affect the balance of fluids and electrolytes in the body. It's important to consult with a healthcare provider for safer alternatives to manage high blood pressure during pregnancy.
Can I take combination of Telmisartan and Hydrochlorothiazide if I am pregnant?
Telmisartan is contraindicated during pregnancy, especially in the second and third trimesters, due to the risk of fetal toxicity, including potential injury or death to the developing fetus. Hydrochlorothiazide crosses the placenta and may cause fetal or neonatal jaundice and thrombocytopenia. Both medications pose significant risks during pregnancy, and women who are pregnant or planning to become pregnant should discuss alternative treatments with their healthcare provider. If pregnancy occurs while taking these medications, they should be discontinued immediately.Can I take combination of Telmisartan and Hydrochlorothiazide while breastfeeding?
There is limited information on the safety of Telmisartan during breastfeeding, and it is generally advised to avoid its use due to potential adverse effects on the infant. Hydrochlorothiazide is present in breast milk, but its effects on milk production and the breastfed infant are not well-documented. Due to the potential for serious adverse reactions, including hypotension and electrolyte imbalances in the infant, breastfeeding mothers are advised to either discontinue the medication or choose an alternative feeding method.Can I take combination of Hydrochlorothiazide and Telmisartan while breastfeeding?
Hydrochlorothiazide is generally considered safe to use during breastfeeding in low doses, as it passes into breast milk in small amounts and is unlikely to affect the baby. However, high doses may reduce milk production.
Telmisartan, on the other hand, has limited information available regarding its safety during breastfeeding. The alternative medications with more established safety profiles during breastfeeding may be preferred.
It's important to consult with a healthcare provider to weigh the benefits and risks before taking these medications while breastfeeding.Who should avoid taking combination of Telmisartan and Hydrochlorothiazide?
Important warnings for Telmisartan and Hydrochlorothiazide include the risk of fetal toxicity if taken during pregnancy, particularly in the second and third trimesters. Patients with severe kidney or liver impairment should use these medications cautiously. Hydrochlorothiazide may cause electrolyte imbalances, while Telmisartan can lead to hypotension, especially in volume-depleted patients. Both medications can cause allergic reactions, and patients should avoid unnecessary sun exposure due to increased skin sensitivity. Regular monitoring and consultation with a healthcare provider are crucial to manage these risks.Who should avoid taking combination of Hydrochlorothiazide and Telmisartan?
People who should avoid taking the combination of Hydrochlorothiazide and Telmisartan include those who are allergic to either of these medications or any of their ingredients. Additionally, individuals with severe kidney or liver problems, or those who have difficulty urinating, should not take this combination. Pregnant women, especially in the second and third trimesters, should avoid it due to potential harm to the unborn baby. It's also not recommended for people with low blood pressure or those who have experienced angioedema, which is swelling under the skin, often around the eyes and lips. Always consult a healthcare provider before starting or stopping any medication.