indomethacin

ENGLISH

Synonyms

Approved Treatment Indication:

Patent Ductus Arteriosus, Gouty Arthritis, Rheumatoid Arthritis, Ankylosing Spondylitis, Pain, Inflammation, Tendinopathy, Bursitis, Osteoarthritis

Summary

  • What conditions Indomethacin is used for

    Indomethacin is used to treat pain and inflammation in conditions like arthritis, which is joint inflammation, gout, which is a type of arthritis caused by uric acid crystals, and bursitis, which is inflammation of fluid-filled sacs in joints. It helps reduce swelling and discomfort.

  • How Indomethacin works in the body

    Indomethacin works by blocking enzymes called COX-1 and COX-2, which produce substances that cause inflammation and pain. This action reduces swelling and discomfort, similar to turning off a faucet to stop water flow.

  • The usual dosages and routes of administration of Indomethacin

    The usual starting dose for adults is 25 mg taken two to three times daily. The maximum recommended dose is 200 mg per day. Indomethacin is usually taken with food to prevent stomach upset. Do not crush or chew the capsules.

  • The most commonly observed adverse effects of Indomethacin

    Common side effects include stomach upset, which refers to discomfort in the stomach, nausea, which is feeling like you might vomit, and dizziness, which is feeling lightheaded or unsteady. These effects are usually mild.

  • Important safety warnings and contraindications of Indomethacin

    Indomethacin can increase the risk of heart attack or stroke, especially with long-term use. It may cause stomach bleeding. Do not use if allergic to NSAIDs, have active stomach ulcers, or severe kidney disease. Consult your doctor before use.

Drug Status

Government Approvals

Government Approvals

US(FDA), UK(BNF)

WHO Essential Medicine

WHO Essential Medicine

NO

Known Teratogen

Known Teratogen

NO

Pharmaceutical Class

Pharmaceutical Class

Nonsteroidal Anti-inflammatory Drug

Controlled Drug Substance

Controlled Drug Substance

NO

Indications and Purpose

  • What is Indomethacin?

    Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation. It works by blocking substances in the body that cause inflammation. It's commonly used for conditions like arthritis and gout.
  • How does Indomethacin work?

    Indomethacin works by blocking enzymes called COX-1 and COX-2, which produce substances that cause inflammation and pain. Think of it like turning off a faucet to stop water flow. This action reduces swelling and discomfort in conditions like arthritis.
  • Is Indomethacin effective?

    Indomethacin is effective for reducing pain and inflammation in conditions like arthritis. It works by blocking substances in the body that cause inflammation. Clinical studies support its effectiveness in managing these symptoms.

Directions for Use

  • What is the usual dose of Indomethacin?

    The usual starting dose of Indomethacin for adults is 25 mg two to three times daily. Your doctor may adjust the dose based on your response and needs. The maximum recommended dose is 200 mg per day. Always follow your doctor's dosing instructions.
  • How do I take Indomethacin?

    Take Indomethacin as prescribed by your doctor. It's usually taken two to three times a day with food to prevent stomach upset. Do not crush or chew the capsules. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. Avoid taking two doses at once.
  • For how long do I take Indomethacin?

    Indomethacin is typically used for short-term relief of pain and inflammation. The duration depends on your condition and doctor's advice. Follow your doctor's instructions and do not use it longer than recommended to avoid side effects.
  • How long does it take for Indomethacin to start working?

    Indomethacin starts working within a few hours to relieve pain and inflammation. Full effects may take a few days. Individual response times can vary based on factors like the condition being treated and overall health.
  • How should I store Indomethacin?

    Store Indomethacin at room temperature, away from moisture and light. Keep it in a tightly closed container. Do not store it in the bathroom, where humidity can affect it. Keep it out of reach of children and pets.
  • How do I dispose of Indomethacin?

    Dispose of Indomethacin by taking it to a drug take-back program or collection site. If unavailable, mix it with undesirable substances like coffee grounds, seal in a plastic bag, and throw it in the trash. Do not flush it down the toilet.

Warnings and Precautions

  • Who should avoid taking Indomethacin?

    Do not use Indomethacin if you have a history of allergic reactions to it or other NSAIDs. It's contraindicated in people with active stomach ulcers or severe kidney disease. Use caution if you have heart disease or high blood pressure. Always consult your doctor before use.
  • Can I take Indomethacin with other prescription drugs?

    Indomethacin can interact with blood thinners like warfarin, increasing bleeding risk. It may also interact with other NSAIDs, raising the chance of stomach issues. Always inform your doctor about all medications you take to avoid harmful interactions.
  • Can Indomethacin be taken safely while pregnant?

    Indomethacin is not recommended during pregnancy, especially in the third trimester. It may affect the baby's heart and blood flow. Limited data exist on its safety, so consult your doctor for advice on managing pain during pregnancy.
  • Can Indomethacin be taken safely while breastfeeding?

    Indomethacin is generally considered safe while breastfeeding, but it can pass into breast milk in small amounts. Monitor your baby for any unusual symptoms. Consult your doctor to discuss the benefits and risks of using Indomethacin while nursing.
  • Is Indomethacin safe for the elderly?

    Elderly individuals are more vulnerable to the side effects of Indomethacin, such as stomach bleeding and kidney problems. It's important to use the lowest effective dose and monitor for adverse effects. Regular check-ups with a doctor are recommended to ensure safety.
  • Is it safe to exercise while taking Indomethacin?

    Yes, you can exercise while taking Indomethacin. However, be aware that it may cause dizziness or stomach upset. Avoid strenuous activities if you experience these symptoms. Stay hydrated and listen to your body during workouts.
  • Is it safe to drink alcohol while taking Indomethacin?

    It's best to avoid alcohol while taking Indomethacin. Alcohol can increase the risk of stomach bleeding and worsen side effects like dizziness. If you choose to drink, do so in moderation and watch for any adverse symptoms.
  • What are the most common side effects of Indomethacin?

    Side effects are unwanted reactions to a medication. Common side effects of Indomethacin include stomach upset, nausea, and dizziness. These effects vary among individuals. If you experience new symptoms, they may be temporary or unrelated. Consult your doctor before stopping the medication.
  • Does Indomethacin have adverse effects?

    Adverse effects are unwanted reactions to a medication. Common adverse effects of Indomethacin include stomach upset, dizziness, and headache. Serious effects like heart attack or stroke are rare but require immediate medical attention. Report any new or worsening symptoms to your doctor.
  • Is Indomethacin addictive?

    Indomethacin is not addictive. It does not cause physical or psychological dependence. You won't experience cravings or withdrawal symptoms when stopping it. Always use it as prescribed by your doctor to manage your condition safely.
  • Does Indomethacin have any safety warnings?

    Yes, Indomethacin has safety warnings. It can increase the risk of heart attack or stroke, especially with long-term use. It may also cause stomach bleeding. Follow your doctor's instructions and report any unusual symptoms like chest pain or severe stomach pain immediately.
  • Is it safe to stop Indomethacin?

    Indomethacin is often used for short-term relief of pain or inflammation. Stopping it suddenly is usually safe, but your symptoms may return. Always consult your doctor before stopping to ensure it's appropriate for your condition.

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