metirosine

ENGLISH

Synonyms

Approved Treatment Indication:

Pheochromocytoma

Summary

  • What conditions metirosine is used for

    Metirosine is used to treat pheochromocytoma, which is a type of tumor that can cause high blood pressure. It helps manage symptoms by reducing the production of certain chemicals in the body.

  • How metirosine works in the body

    Metirosine works by inhibiting the production of catecholamines, which are chemicals that can raise blood pressure. This helps lower blood pressure and manage symptoms associated with pheochromocytoma.

  • The usual dosages and routes of administration of metirosine

    The usual starting dose of metirosine for adults is 250 mg four times a day. It can be taken with or without food, and the maximum recommended dose is 4 grams per day.

  • The most commonly observed adverse effects of metirosine

    Common side effects of metirosine include drowsiness and diarrhea. These effects vary from person to person, and if you notice new symptoms, talk with your doctor.

  • Important safety warnings and contraindications of metirosine

    Metirosine can cause drowsiness, so avoid driving or operating heavy machinery until you know how it affects you. It should be used with caution in people with kidney problems.

Drug Status

Government Approvals

Government Approvals

US(FDA)

WHO Essential Medicine

WHO Essential Medicine

NO

Known Teratogen

Known Teratogen

NO

Pharmaceutical Class

Pharmaceutical Class

Catecholamine Synthesis Inhibitor

Controlled Drug Substance

Controlled Drug Substance

NO

Indications and Purpose

  • What is metirosine?

    Metirosine is a medication used to treat pheochromocytoma, which is a type of tumor that can cause high blood pressure. It works by reducing the production of certain chemicals in the body that can raise blood pressure. Metirosine is usually used in combination with other therapies to manage symptoms effectively.
  • How does metirosine work?

    Metirosine works by inhibiting the production of catecholamines, which are chemicals that can raise blood pressure. Think of it like turning down the volume on a loudspeaker. By reducing these chemicals, metirosine helps lower blood pressure and manage symptoms associated with pheochromocytoma.
  • Is metirosine effective?

    Metirosine is effective in treating pheochromocytoma, which is a type of tumor that can cause high blood pressure. It works by reducing the production of certain chemicals in the body that can raise blood pressure. Clinical studies support its effectiveness in managing symptoms associated with this condition.

Directions for Use

  • What is the usual dose of metirosine?

    The usual starting dose of metirosine for adults is 250 mg four times a day. Your doctor may adjust your dose based on your response and needs. The maximum recommended dose is 4 grams per day. Always follow your doctor's specific dosing instructions for your personal health needs. Dose adjustments may be necessary for special populations such as children or the elderly.
  • How do I take metirosine?

    Take metirosine as directed by your doctor, usually 2 to 4 times daily. You can take it with or without food. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not double up on doses. Always follow your doctor's specific instructions regarding diet and fluid intake while on this medication.
  • For how long do I take metirosine?

    Metirosine is usually used for long-term management of pheochromocytoma, which is a type of tumor that can cause high blood pressure. You'll typically take metirosine every day as a lifelong treatment unless your doctor suggests otherwise. Always talk with your doctor before changing or stopping your metirosine treatment.
  • How long does it take for metirosine to start working?

    Metirosine begins working in your body shortly after you take it. However, you may not notice all the benefits right away. It may take several days to weeks to see significant improvements in symptoms like high blood pressure. How quickly the medication works can depend on your overall health and response to treatment.
  • How should I store metirosine?

    Store metirosine at room temperature, away from moisture and light. Keep it in a tightly closed container to protect it from damage. Don't store your medicine in humid places like bathrooms. Always store metirosine out of children's reach to prevent accidental swallowing. Check the expiration date regularly and dispose of any unused or expired medication properly.
  • How do I dispose of metirosine?

    Bring unused metirosine to a drug take-back program or collection site at a pharmacy or hospital. If you can't find a take-back program, you can throw it in the trash at home. First, take it out of its original container, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.

Warnings and Precautions

  • Who should avoid taking metirosine?

    Don't take metirosine if you're allergic to it or its ingredients. Serious allergic reactions require immediate medical help. Metirosine should be used with caution in people with kidney problems, as it may worsen kidney function. Always consult your doctor about any concerns or conditions you have before starting metirosine.
  • Can I take metirosine with other prescription drugs?

    Metirosine can interact with other medications, increasing the risk of side effects like drowsiness. It's important to inform your doctor about all the medications you're taking, including over-the-counter drugs and supplements. Your doctor can help manage any potential interactions and adjust your treatment plan as needed.
  • Can metirosine be taken safely while pregnant?

    The safety of metirosine during pregnancy is not well-established. Limited evidence makes it difficult to provide definitive advice. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition. Your doctor can help create a treatment plan that protects both you and your baby.
  • Can metirosine be taken safely while breastfeeding?

    The safety of metirosine while breastfeeding is not well-established. We don't have much information about whether this medication passes into human breast milk. If you're taking metirosine and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
  • Is metirosine safe for the elderly?

    Elderly individuals may be more vulnerable to the side effects of metirosine, such as drowsiness and dizziness. These effects can increase the risk of falls or injuries. It's important for elderly patients to be closely monitored by their doctor while taking metirosine. Dose adjustments may be necessary to ensure safety.
  • Is it safe to exercise while taking metirosine?

    You can exercise while taking metirosine, but keep a few things in mind. This medication can cause drowsiness, which might make you feel dizzy during exercise. To exercise safely, drink plenty of water before, during, and after physical activity. Watch for signs of dizziness or unusual fatigue and rest if needed.
  • Is it safe to drink alcohol while taking metirosine?

    It's best to avoid alcohol while taking metirosine. Alcohol can increase the risk of side effects like drowsiness and dizziness. If you do choose to drink occasionally, limit how much alcohol you consume and watch for warning signs like dizziness or confusion. Talk with your doctor about alcohol use while taking metirosine.
  • What are the most common side effects of metirosine?

    Side effects are unwanted reactions that can happen when taking a medication. Common side effects of metirosine include drowsiness and diarrhea. These effects vary from person to person. If you notice new symptoms after starting metirosine, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
  • Does metirosine have adverse effects?

    Adverse effects are unwanted reactions to a medication. Common adverse effects of metirosine include drowsiness and diarrhea. Serious side effects can include confusion or tremors. If you experience any new or worsening symptoms, contact your doctor. They can help determine if these symptoms are related to metirosine and recommend appropriate action.
  • Is metirosine addictive?

    Metirosine is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. It works by affecting your body's production of certain chemicals, not brain chemistry, so it doesn't lead to addiction. If you have concerns about medication dependence, you can feel confident that metirosine doesn't carry this risk.
  • Does metirosine have any safety warnings?

    Metirosine has important safety warnings. It can cause drowsiness, so avoid driving or operating heavy machinery until you know how it affects you. Not adhering to safety warnings can lead to accidents or injuries. Always follow your doctor's advice and report any unusual symptoms or side effects you experience while taking metirosine.
  • Is it safe to stop metirosine?

    Stopping metirosine suddenly can cause your symptoms to return or worsen. It's important to talk with your doctor before stopping this medication. They might suggest gradually reducing your dose to avoid any potential issues. Your doctor will help you make any medication changes safely to protect your health.

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