ursodeoxycholic acid
Synonyms
Approved Treatment Indication:
Biliary Liver Cirrhosis, Cholelithiasis
Summary
What conditions Ursodeoxycholic acid is used for
Ursodeoxycholic acid is used to treat primary biliary cholangitis, which is a disease that damages the bile ducts in the liver. It helps improve liver function and can also be used for other liver conditions as determined by your doctor.
How Ursodeoxycholic acid works in the body
Ursodeoxycholic acid works by reducing cholesterol production and dissolving cholesterol in bile, which helps improve liver function. It acts like a detergent that breaks down fats, clearing bile from the liver and reducing liver damage.
The usual dosages and routes of administration of Ursodeoxycholic acid
The usual starting dose for adults is 8-10 mg per kilogram of body weight per day, divided into two or three doses. It's taken with meals, and tablets should be swallowed whole with water. Your doctor may adjust the dose based on your response.
The most commonly observed adverse effects of Ursodeoxycholic acid
Common side effects include diarrhea, nausea, and abdominal pain, which are usually mild. These effects may improve as your body adjusts to the medication. If you experience severe or persistent symptoms, consult your doctor.
Important safety warnings and contraindications of Ursodeoxycholic acid
Do not take Ursodeoxycholic acid if you have a complete bile duct blockage or certain liver conditions. Caution is needed during pregnancy and breastfeeding. Always inform your doctor about your medical history before starting this medication.
Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Bile Acid
Controlled Drug Substance
NO
Indications and Purpose
What is Ursodeoxycholic Acid?
Ursodeoxycholic acid (UDCA) is primarily used to treat certain liver conditions, such as primary biliary cholangitis and gallstones. It works by reducing the production of cholesterol in the liver and improving bile flow, which helps dissolve gallstones and prevents the buildup of toxic bile acids. UDCA also has a protective effect on liver cells, promoting liver health.
How does Ursodeoxycholic Acid work?
Ursodeoxycholic acid works by reducing the production of cholesterol in the liver and improving bile flow. It helps to dissolve cholesterol-based gallstones by decreasing the cholesterol content of bile. In liver diseases, it protects liver cells by reducing the toxicity of bile acids, promoting liver function, and decreasing inflammation. This results in improved bile circulation and liver health.
Is Ursodeoxycholic Acid effective?
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Directions for Use
What is the usual dose of Ursodeoxycholic acid?
The usual starting dose of Ursodeoxycholic acid for adults is 8-10 mg per kilogram of body weight per day, divided into two or three doses. Your doctor may adjust the dose based on your response and specific health needs. Always follow your doctor's dosing instructions. For children or the elderly, dose adjustments may be necessary, so consult your healthcare provider for personalized advice.How do I take Ursodeoxycholic Acid?
Ursodeoxycholic acid should be taken with food to enhance absorption and reduce potential gastrointestinal irritation. There are no specific food restrictions while using this medication, but it is recommended to maintain a balanced diet. Patients should avoid taking the medication with antacids containing aluminum hydroxide, as they can interfere with its effectiveness. Always follow the dosage instructions provided by the healthcare provider.
For how long do I take Ursodeoxycholic acid?
Ursodeoxycholic acid is usually a long-term medication for managing chronic liver conditions like primary biliary cholangitis. You'll typically take it every day as a lifelong treatment unless your doctor suggests otherwise. Stopping this medication without medical advice could cause your condition to worsen. How long you'll need this medication depends on your body's response and any side effects you experience. Always talk with your doctor before changing or stopping your treatment.How long does it take for Ursodeoxycholic Acid to start working?
Ursodeoxycholic acid can take several weeks to months to show noticeable effects, depending on the condition being treated. For example, in patients with gallstones, it may take 6 to 12 months to dissolve the stones completely. For liver diseases like primary biliary cholangitis, improvements in liver function may be seen within 3 to 6 months, but full benefits may take longer.
How should I store Ursodeoxycholic Acid?
Ursodeoxycholic Acid should be stored at room temperature, between 68°F and 77°F (20°C and 25°C). The medication should be kept in a tightly closed container, away from light, heat, and moisture.
How do I dispose of Ursodeoxycholic acid?
To dispose of Ursodeoxycholic acid, bring unused medicines to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so it doesn't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
Warnings and Precautions
Who should avoid taking Ursodeoxycholic Acid?
UDCA can cause severe diarrhea, nausea, and vomiting in some patients. If these symptoms occur, contact your doctor immediately.
UDCA can cause liver damage in patients with advanced cirrhosis or other severe liver disease.
UDCA can increase the risk of bleeding, particularly in patients with a history of bleeding disorders or who are taking blood-thinning medications.
Can I take Ursodeoxycholic Acid with other prescription drugs?
UDCA can interact with statins and increase the risk of liver damage.
UDCA can interact with blood-thinning medications and increase the risk of bleeding.
UDCA can interact with certain antibiotics and reduce their effectiveness.
Can Ursodeoxycholic Acid be taken safely while pregnant?
Ursodeoxycholic Acid (UDCA) is generally considered safe for use during pregnancy. Animal studies have not shown any evidence of harm to the fetus, and there is limited data available from human studies. However, UDCA should only be used during pregnancy if the benefits to the mother outweigh the risks to the fetus.
Can Ursodeoxycholic Acid be taken safely while breastfeeding?
Ursodeoxycholic Acid (UDCA) can pass into breast milk, and it's not known if it can harm a nursing baby. However, it's generally considered safe for breastfeeding mothers to take UDCA.
Women who are breastfeeding and need to take UDCA should monitor their baby closely for any signs of side effects, such as diarrhea, vomiting, or poor weight gain.
Is Ursodeoxycholic acid safe for the elderly?
Elderly individuals may be more vulnerable to the side effects of Ursodeoxycholic acid, such as diarrhea or abdominal pain. However, it is generally considered safe for elderly patients when used as directed. Regular monitoring by a healthcare provider is important to ensure the medication is working effectively and to adjust the dose if necessary. Always consult your doctor for personalized advice.Is it safe to exercise while taking Ursodeoxycholic acid?
You can exercise while taking Ursodeoxycholic acid, but keep a few things in mind. This medication can cause mild stomach upset, which might affect your comfort during exercise. To exercise safely, listen to your body and avoid strenuous activities if you feel unwell. Most people can maintain their regular exercise routine while taking Ursodeoxycholic acid, but check with your doctor if you have concerns.Is it safe to drink alcohol while taking Ursodeoxycholic acid?
It's best to avoid alcohol while taking Ursodeoxycholic acid. Alcohol can strain the liver, which may interfere with the medication's effectiveness and worsen liver conditions. If you do choose to drink occasionally, limit your alcohol intake and discuss it with your doctor. They can provide personalized advice based on your specific health situation.What are the most common side effects of Ursodeoxycholic acid?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Ursodeoxycholic acid include diarrhea, nausea, and abdominal pain. These effects are usually mild and may improve as your body adjusts to the medication. If you notice new symptoms after starting Ursodeoxycholic acid, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.Does Ursodeoxycholic acid have adverse effects?
Adverse effects are unwanted reactions to a medication. Ursodeoxycholic acid is generally well-tolerated, but some people may experience diarrhea, nausea, or abdominal pain. These effects are usually mild. Serious side effects are rare but can include liver problems. If you notice any new or worsening symptoms, contact your doctor. They can help determine if the symptoms are related to the medication and advise on the best course of action.Is Ursodeoxycholic acid addictive?
Ursodeoxycholic acid is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. It works by affecting bile acids in the liver and doesn't impact brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, Ursodeoxycholic acid doesn't carry this risk.Does Ursodeoxycholic acid have any safety warnings?
Ursodeoxycholic acid has safety warnings you should know about. It may not be suitable for people with certain liver conditions or blockages in the bile duct. Not adhering to these warnings can lead to worsening liver function or other complications. Always inform your doctor about your medical history and any symptoms you experience while taking this medication. Follow your doctor's advice to ensure safe use.Is it safe to stop Ursodeoxycholic acid?
It's important to talk with your doctor before stopping Ursodeoxycholic acid. This medication is often used long-term for chronic conditions like liver disease. Stopping it suddenly may worsen your condition. Your doctor can guide you on how to safely stop or adjust your medication if needed. They might suggest gradually reducing your dose or switching to a different treatment to keep your condition under control.